Pair Name	Quercetin, Docetaxel
Disease Info	[ICD-11: 2C82.0]	Prostate cancer		Investigative
Biological Phenomena	Induction-->Proliferation and apoptosis
In Vitro Model	DU145	Prostate carcinoma	Homo sapiens (Human)	CVCL_0105
	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
Result	Combination Modality Using Quercetin to Enhance the Efficacy of Docetaxel in Prostate Cancer Cells

Pair Name	Quercetin, Docetaxel
Disease Info	[ICD-11: 2E02]	Metastatic prostate cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	AR	hsa367
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	ABCB1	hsa5243
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
In Vitro Model	PC-3-R	Prostate carcinoma	Homo sapiens (Human)	CVCL_C0QS
	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
In Vivo Model	5×10⁵ PC-3 cells were suspended in 100 μL PBS, or 2×108 LNCaP cells were suspended in 100 μL of matrigel, while PBS mixture (1:1) were injected subcutaneously into the right axillary fossa of mice.
Result	Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways